1049-107 Natriuretic peptides as predictors of clinical course in patients with end-stage heart failure
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چکیده
منابع مشابه
Natriuretic peptides in heart failure.
Heart failure is a major global health problem affecting 23 million people worldwide. As more cardiac patients survive and live longer with this progressive disease, heart failure is a condition for which the prevalence will grow. Based solely on clinical presentation, heart failure can be difficult to diagnose since its presentation is complex, with signs and symptoms that are nonspecific and ...
متن کاملNatriuretic peptides - physiology, pathophysiology and clinical use in heart failure.
The natriuretic peptides - atrial, brain and C-type - were discovered during the last twenty years. Their effects on cardiovascular, renal, cerebral and other tissues through guanylyl cyclase were uncovered. Over the past decade natriuretic peptides (NPs) became a very useful tool in the management of heart failure patients. Results of many clinical trials have shown that BNP and NT-proBNP are ...
متن کاملDesigner natriuretic peptides for heart failure: advanced in clinical development
Background The increasing burden of heart failure (HF) is a major unmet need for new therapeutics. No new drug has been approved for HF for over a decade. The natriuretic peptides as endogenous activators of particulate guanylyl cyclase (GC) receptors represent an unparalleled opportunity for novel therapeutic agents for HF. Specifically, the GC-A receptor activated by ANP and BNP and GCB activ...
متن کاملPreliminary clinical experience with the repetitive administration of levosimendan in patients with end-stage heart failure.
We present our preliminary clinical experience with the initial and repetitive administration of the novel inotropic agent levosimendan in a cohort of 20 patients with end-stage heart failure who were acutely decompensated or whose symptoms were refractory to the usual pharmacological treatments thus necessitating hospitalization. Repetitive levosimendan infusions were administered to 9 patient...
متن کاملNatriuretic peptides, heart failure and LCZ696 (Entresto®)
Both BNP and NT-proBNP are considered to be gold standard biomarkers of HF. Both of these are also incorporated into the majority of the national and international cardiovascular therapy guidelines. However, despite this, our understanding of their very complex nature is still far from being complete and comprehensive. Moreover, the constant development of new approaches in patient care and the...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2004
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(04)90724-3